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LSD was first invented in 1938 by a famous Swiss chemist named Albert Hoffmann. He was also the same man to isolate psilocybin and psilocin from magic mushrooms for the first time.

Hoffmann discovered acid by accident while working for the pharmaceutical company, Sandoz. He was searching for a new drug to help with uterine contractions during pregnancy. LSD, as we know it today, was the 25th compound he synthesized from compounds he extracted from a rye fungus called ergot. His notes listed the compound as LSD-25 — which remains a common name for the drug to this day.

After inventing LSD-25, it was quickly ruled out for having no impact on affecting uterine contractions, so it was shelved for about five years.

In 1943, Hoffmann returned to ergot and resynthesized LSD-25 and other compounds to perform some experiments.

Somehow or another, a few drops of LSD-25 ended up on his skin. About an hour later, he started to experience a “not unpleasant intoxicated like condition, characterized by an extremely stimulated imagination.”

After this experience, Hoffman became understandably interested in LSD-25 and dedicated the subsequent several years towards further testing the compound for potential medical applications and toxicity. The first clinical trials for the new drug began in 1947 in a psychiatric hospital in Basel, Switzerland.

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LSD is a semi-synthetic derivative of a group of compounds called lysergamides. These compounds are primarily found in a species of rye fungus called ergot.

LSD works by activating serotonin receptors in the brain — which produces changes in visual, auditory, and tactile perception. It promotes introspection and the dissolving of the “ego.”

An acid trip can last anywhere from 8 to 12 hours.

Conventional uses of acid revolved around self-growth and spiritual exploration — but research has also shown a lot of promise for LSD as a treatment for psychiatric disorders. It has the ability to “reset” the default mode network — which is a series of brain processes that control our inner sense of self-worth and ego. Hyperactivity in the default mode network has been linked with depression, anxiety, obsessive-compulsive disorder, addiction, and more.

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The chemical structure of LSD is similar to serotonin — which is one of the most influential neurotransmitters in the brain. Serotonin is responsible for regulating mental processes such as mood, arousal, eating habits, digestion, and much more.

The similarities in structure allow LSD to interact with the serotonin receptors [5,8]. In particular, LSD targets 5-HT2A and 5-HT2C receptors. These receptors are responsible for the psychoactive effects of LSD and other tryptamine-based psychedelics (such as DMT or psilocybin).

LSD is different from other psychedelics in that it can also activate the dopamine D2 receptors. This ability to modulate the balance between serotonin and dopamine activity is thought to be how LSD provides its powerful hallucinogenic and introspective qualities

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There are over 60 years of research to prove LSD is both non-toxic and non-addictive. There have never been any reported overdose cases from people taking too much LSD, and there’s no indication of addiction to LSD.

Tolerance formation is possible in people who take LSD often — prompting them to take larger doses to get the same effect. However, when they stop taking LSD, no symptoms of withdrawal or cravings are reported.

The best way to assess the toxicity of a drug is to find the LD50. This is a term used in medical research that describes the amount of a drug needed to kill roughly 50% of the study participants (usually mice).

There has yet to be an established LD50 for LSD. Even exceptionally high doses of the drug are non-lethal.

In the 1970s, a group of party attendees mistakenly snorted between 1000 and 7000 micrograms of LSD in powder form after mistaking it for cocaine [4]. This is equivalent to taking roughly 100 doses of acid at once. Some of the people in this group experienced problems with bleeding in the digestive tract, vomiting, and temporary comatose states. Everybody in this group survived the incident unharmed.

Despite the high level of safety, there are some potential risks to using LSD. During the trip, visions and hallucinations can cause bouts of anxiety, paranoia, and intense fearsome of which can cause long-term mental harm.

Another long-term (albeit rare) side-effect that can result from LSD use is a condition called hallucinogen persisting perception disorder (HPPD). This disorder is characterized by long-lasting changes to visual or auditory sensory information — sometimes lasting several months or years after the initial trip.

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